Southall & Brent Revisited (SABRE)

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Overview

Aims
The Southall And Brent REvisited Study (SABRE) is the largest tri-ethnic population-based cohort in the UK, involving nearly 5000 European, Indian Asian and African Caribbean men and women. The study originally focused on the causes of diabetes and disorders of the heart and circulation, broadening this focus to include cognitive function in the follow up stages. The participants were aged 40-69 when first studied in the two Southall and Brent studies between 1989 and 1991. Over 2008-2011 participants were followed up in a comprehensive combined morbidity and mortality study.

Institution
Institute of Cardiovascular Science, University College London

Geographic coverage
England - London (Southall & Brent)

Start date
1988

Sample

Sample type
Cohort study

Sample details
The Southall study (1988–90) was the first of the two baseline studies. A target sample of 3000 men aged 40–69 years of Indian Asian and European descent was chosen. The sample was assembled from two sources selected for the ethnic mix of the potential participants: industrial workforces and general practitioners’ lists. The general practice component was supplemented with a target sample of 600 women and was drawn from 16 general practices in the Southall and Greenford areas of west London. A small number of African Caribbean participants who appeared in this sampling frame were also included. For the industrial sample, four factories in West London were chosen. Overall, 1711 Indian Asian participants and 2004 non-Asian participants were recruited to the Southall study.

In the Brent Study (1990–91), the target sample was based on the lists of six general practices. A target sample of 300 participants in each sex and ethnic group (European and African Caribbean) aged 40–69 years was chosen. With the help of practice staff, potential participants were assigned to one of five ethnic groups: European, South Asian, African Caribbean, other and unknown. A random sample from the combined African Caribbean and unknown group, stratified by 5-year age group and sex, was selected, and an equal sample of Europeans was chosen in the same manner. 578 African Caribbean participants and 585 European participants were recruited to the study.

All South Asian and African Caribbean participants are first-generation migrants to the UK.

Sample size at recruitment
4858

Sample size at most recent sweep
2,572 (SABRE V2)

Sex
All

Age at recruitment
40-69 years

Cohort year of birth
1919-50

Data

Data access
Contact study team iris.ucl.ac.uk/iris/browse/researchActivity/17541

Genetic data collected

Linkage to administrative data

Additional information

Website
mrc.ukri.org/research/facilities-and-resources-for-researchers/cohort-directory/southall-and-brent-revisited-sabre

Related Themes
Ageing, biomarkers, cognitive measures, diet and nutrition, ethnicity and race, genetic data, COVID

Reference paper

Tillin, T, Forouhi, NG, McKeigue, PM et al. (2012). Southall And Brent REvisited: Cohort profile of SABRE, a UK population-based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins. International Journal of Epidemiology, 41: 31-32.
doi.org/10.1093/ije/dyq175

Funders
Wellcome Trust
British Heart Foundation
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